abstract：:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls w...

journal_title：Psychiatry research

authors： Arora RC,Meltzer HY

更新日期：1982-06-01 00:00:00

abstract：:Five women with primary major bipolar affective disorders had variable and at times very high urinary phenylethylamine (PEA) excretion rates. The clinical picture of these patients was characterized by periodic bizarre behaviors and short psychotic episodes. These patients were generally nonresponsive to the usual tre...

journal_title：Psychiatry research

authors： Karoum F,Linnoila M,Potter WZ,Chuang LW,Goodwin FK,Wyatt RJ

更新日期：1982-04-01 00:00:00

abstract：:Blood from chronic schizophrenic patients in two hospitals (A and B) and from institutional and noninstitutional controls was analyzed for platelet monoamine oxidase (MAO) activity toward three different substrates (tryptamine, phenylethylamine, and p-tyramine) and for plasma levels of conjugated and unconjugated phen...

journal_title：Psychiatry research

authors： Davis BA,Yu PH,Carlson K,O'Sullivan K,Boulton AA

更新日期：1982-02-01 00:00:00

abstract：:In a study of 80 patients who received 164 treatments with sleep deprivation, the following questions were addressed: Do depressive patients of different subgroups respond differently to sleep deprivation? what complications arise? does the same patient react in the same way to multiple treatments? are there differenc...

journal_title：Psychiatry research

authors： Fähndrich E

更新日期：1981-12-01 00:00:00

abstract：:Somatosensory evoked potential (SEP) late waves (P400) associated with selective attention were elicited by having subjects count electrical stimuli to one of four randomly stimulated fingers. P400 amplitude was lower in a diagnostically heterogeneous group of 20 psychiatric patients than in 16 nonpatients. Among pati...

journal_title：Psychiatry research

authors： Josiassen RC,Shagass C,Roemer RA,Straumanis JJ

更新日期：1981-10-01 00:00:00

abstract：:Serum prolactin levels were monitored for 2 hours after injection of chlorpromazine (CPZ) 50 mg intramuscularly (i.m.) in 6 male normal controls and 14 newly admitted male chronic schizophrenics. The increase in serum prolactin levels in the male normal controls was not significantly different from that in patients. S...

journal_title：Psychiatry research

authors： Meltzer HY,Busch DA,Creese IR,Snyder SH,Fang VS

更新日期：1981-08-01 00:00:00

abstract：:Event-related potentials in two auditory target detection paradigms and two auditory paradigms without overt tasks were studied in 22 schizophrenic, 21 depressed, and 28 matched control subjects meeting Research Diagnostic Criteria. In the target detection paradigms, schizophrenics showed a pattern of reduced N120 amp...

journal_title：Psychiatry research

authors： Roth WT,Pfefferbaum A,Kelly AF,Berger PA,Kopell BS

更新日期：1981-04-01 00:00:00

abstract：:This study test the effects on autonomic nervous system (ANS) activity of two doses (0.25 mg/kg and 0.50 mg/kg) of dextroamphetamine in normal men. Skin conductance and heart rate were recorded during rest, tone presentation, and a reaction time task. Compared to placebo, dextroamphetamine increased both skin conducta...

journal_title：Psychiatry research

authors： Zahn TP,Rapoport JL,Thompson CL

更新日期：1981-02-01 00:00:00

abstract：:The symptom scores on the Schedule for Affective Disorders and Schizophrenia (SADS) of 21 unipolar and 12 bipolar depressive patients diagnosed with Research Diagnostic Criteria (RDC) were correlated with the monoamine metabolites homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacet...

journal_title：Psychiatry research

authors： Agren H

更新日期：1980-10-01 00:00:00

abstract：:No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (thr...

journal_title：Psychiatry research

authors： Breakefield XO,Giller EL Jr,Nurnberger JI Jr,Castiglione CM,Buchsbaum MS,Gershon ES

更新日期：1980-07-01 00:00:00

abstract：:Choline chloride (2g q.i.d.) and placebo were admin stered to nine young adults in a placebo-drug-placebo design. Subjects took memory tests at the end of both placebo periods and at the end of the choline period. All nine subjects had participated in a previous study in which 1.0 mg of physostigmine infused over a 1-...

journal_title：Psychiatry research

authors： Mohs RC,Davis KL

更新日期：1980-05-01 00:00:00

abstract：:To test the clinical efficacy of low dose fluphenazine decanoate (1.25 mg to 5.0 mg biweekly), we carried out two separate experiments: (1) an open trial in 57 schizophrenic outpatients, lasting 6 months; (2) a double-blind, placebo-controlled discontinuation study in a subgroup of patients who maintained good remissi...

journal_title：Psychiatry research

authors： Kane JM,Rifkin A,Quitkin F,Nayak D,Saraf K,Ramos-Lorenzi JR,Klein DF,Sachar EJ

更新日期：1979-12-01 00:00:00

abstract：:Before a double-blind controlled study of zimelidine, a new, rather specific inhibitor of serotonin uptake, in patients with chronic pain, visual evoked potentials (EPs) to stimuli of varying intensities were recorded. During the trial the blood levels of zimelidine and its active metabolite norzimelidine were estimat...

journal_title：Psychiatry research

authors： von Knorring L,Johansson F

更新日期：1979-12-01 00:00:00

abstract：:Before and after a double-blind trial of haloperidol vs. mesoridazine, 24 hospitalized schizophrenics performed visual perception tasks designed to assess function of the cerebral hemispheres. Tasks involved identifying as "same" or "different" two images (either letters, digits, or unfamiliar shapes) projected tachis...

journal_title：Psychiatry research

authors： Eaton EM,Busk J,Maloney MP,Sloane RB,Whipple K,White K

更新日期：1979-12-01 00:00:00

abstract：:Neuroendocrine studies that examine the changes in serum prolactin levels following intramuscular (im) neuroleptics have usually monitored prolactin levels before and for 90 minutes to 3 hours after neuroleptic injection. Recent studies have suggested that this may be an inadequate period of time. In the present study...

journal_title：Psychiatry research

authors： Busch DA,Fang VS,Meltzer HY

更新日期：1979-10-01 00:00:00

abstract：:Scores on 17 psychological dimensions of the Gottschalk-Gleser content analysis scales were obtained from 5-minute speech samples of 37 white children hospitalized on the psychiatric service of a general hospital. These content analysis scores were compared to identical scores obtained from a normative sample of 109 w...

journal_title：Psychiatry research

authors： Gottschalk LA,Uliana RL,Hoigaard JC

更新日期：1979-07-01 00:00:00